Contact US

Access hundreds of PDC models

Ready to use at every stage of the drug discovery and development pipeline

 

Access hundreds of PDC models

Ready to use at every stage of the drug discovery and development pipeline

 

Well characterised, low-passage, clinically-relevant PDC models derived from our patient diagnostic platform

The predictTx platform is Imagen’s suite of in-vitro pharmacology services for the drug discovery and development community. By harnessing the power of our biobank, with 100’s of clinically relevant 2D and 3D patient derived cell (PDC) models recapitulating the phenotype and genotype of parent tumours. We offer access to an unrivalled breadth of PDC models and related data, and can help you make rapid, informed decisions on which investigational compounds to progress.

Use cases

How you can utilise PDC models in your programmes

Facilitate rapid drug discovery and development by screening your compounds on our PDC models.

Routine Screening

Screen early investigational compounds on patient models in real time.

Targeted Screening

Design your ideal study by selecting from Imagen’s biobank of fully-characterised PDC models.

Bespoke Model Build

Using Imagen’s global clinical network, identify a specific patient group to develop PDC models.

Co-clinical Trial Screening

Imagen are ready to develop PDC models from your clinical trial patients, supporting ongoing translational research.

The Imagen biobank

The PDC models we develop come from a global clinical network that spans a broad demographic base.

Models fully characterised

  • Clinical history

  • Patient treatment history

  • Phenotypic drug response data to ~60 approved clinical drugs (including SOC)

  • NGS (WES and RNAseq)

  • Post-collection treatment responses

Our growing biobank of models is more than 90% accurate in predicting clinical response.

Our growing biobank of models is more than 90% accurate in predicting clinical response.

Select from our comprehensive range of models to help you build the data set you need

PDC development cycle

Patients

Find relevant therapies

1. Collect & Develop

Fresh tumour sample collected from patient, brought to our lab and developed into a PDC.

2. Analyse & Report

Around 60 drugs dosed on sample. Effects analysed using high-content screening. Results highlight suitable treatments and reported to oncologist.

3. Expand & Bank

PDC expanded and cryogenically preserved in Imagen biobank.

Scientists

Rapid discovery and development of new therapies

3. Analyse & Generate

Analyse data and generate endpoints (IC50’s, amongst others).

2. Run Experiment

Re-derive and grow PDC models, dose according to protocol.

1. Design Experiment

Agree objectives and select from 100’s of PDC models in our database (fully characterised, including WES/RNAseq).

PDC development cycle

Patients

Find relevant therapies

1. Collect & Develop

Fresh tumour sample collected from patient, brought to our lab and developed into a PDC.

2. Analyse & Report

Around 60 drugs dosed on sample. Effects analysed using high-content screening. Results highlight suitable treatments and reported to oncologist.

3. Expand & Bank

PDC expanded and cryogenically preserved in Imagen biobank.

Scientists

Rapid discovery and development of new therapies

1. Design Experiment

Agree objectives and select from 100’s of PDC models in our database (fully characterised, including WES/RNAseq).

2. Run Experiment

Re-derive and grow PDC models, dose according to protocol.

3. Analyse & Generate

Analyse data and generate endpoints (IC50’s, amongst others).

Want to discuss how you can gain access to our PDC models and services?

Get in touch

Privacy Settings
We use cookies to enhance your experience while using our website. If you are using our Services via a browser you can restrict, block or remove cookies through your web browser settings. We also use content and scripts from third parties that may use tracking technologies. You can selectively provide your consent below to allow such third party embeds. For complete information about the cookies we use, data we collect and how we process them, please check our Privacy Policy
Youtube
Consent to display content from Youtube
Vimeo
Consent to display content from Vimeo
Google Maps
Consent to display content from Google
Spotify
Consent to display content from Spotify
Sound Cloud
Consent to display content from Sound
Contact Us

© Copyright 2020 Imagen Therapeutics Ltd