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Mission

We’re building the world’s most advanced biobank to transform oncological therapies for patients

Imagen is helping patients and industry find the link between each patient’s unique cancer and the treatments that are going to work for them.

What we do

Cancer is not a single disease

Every patient’s cancer is genetically unique, with a distinct signature of biomarkers that drive the malignancy. Imagen has developed a proprietary in-vitro, drug-sensitivity test, one of the only assays of its kind that can:

Improve outcomes for patients
Help oncologists select the right treatments
Enable scientists to accelerate their drug discovery and development programmes

We offer a diagnostic tool (predictRx) to cancer patients and their doctors, as well as contract research services (predictTx) to the cancer research community.


Improve outcomes for patients
Help oncologists select the right treatments
Enable scientists to accelerate their drug discovery and development programmes

We offer a diagnostic tool (predictRx) to cancer patients and their doctors, as well as contract research services (predictTx) to the cancer research community.

Our platforms

Patients

Find relevant therapies

1. Collect & Develop

Fresh tumour sample collected from patient, brought to our lab and developed into a PDC.

2. Analyse & Report

Around 60 drugs dosed on sample. Effects analysed using high-content screening. Results highlight suitable treatments and reported to oncologist.

3. Expand & Bank

PDC model expanded and cryogenically preserved in Imagen biobank.

Scientists

Rapid discovery and development of new therapies

3. Analyse & Report Experiment

Generate endpoints (IC50s amongst others) and analyse data.

2. Run Experiment

Re-derive and grow PDC models, dose according to protocol.

1. Design Experiment

Agree objectives and select from 100s of PDC models in our database (fully characterised, including WES/RNAseq).

Our platforms

Patients

Find relevant therapies

1. Collect & Develop

Fresh tumour sample collected from patient, brought to our lab and developed into a PDC.

2. Analyse & Report

Around 60 drugs dosed on sample. Effects analysed using high-content screening. Results highlight suitable treatments and reported to oncologist.

3. Expand & Bank

PDC model expanded and cryogenically preserved in Imagen biobank.

Scientists

Rapid discovery and development of new therapies

1. Design Experiment

Agree objectives and select from 100’s of PDC models in our database (fully characterised, including WES/RNAseq).

2. Run Experiment

Re-derive and grow PDC models, dose according to protocol.

3. Analyse & Generate

Analyse data and generate endpoints (IC50’s, amongst others).

The technology

Our cutting-edge science

Imagen’s methodology produces phenotypic clinical drug response data, leveraging automated fluorescence microscopy (high content analysis). We use a proprietary cell medium to enhance cell growth and select for specific neoplastic (cancerous) cell proliferation, thereby creating a low-passage, clinically-relevant patient-derived cancer (PDC) model. These PDC models have been shown to recapitulate various biological characteristics of the parent tumour.

Imagen develop both 2D and sophisticated 3D PDC models, for more complex requirements.

2D and 3D PDC Models

Our vision

We’re working hard to improve outcomes for cancer patients by accelerating drug discovery and the development of new cancer therapies. Our vision is to create the world’s leading biobank of clinically relevant patient-derived cancer (PDC) models whilst building one of the most comprehensive and diverse big data sets available in cancer research. 

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